2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-125954A
    Uridine diphosphate glucuronic acid ammonium 43195-60-4 99.9%
    Uridine diphosphate glucuronic acid ammonium (UDP-α-D-glucuronic acid ammonium) is a glucuronic acid donor. Uridine diphosphate glucuronic acid ammonium transfers its glucuronic acid moiety to acceptor molecules, thereby forming "ether" glucuronides, while being converted into uridine 5'-pyrophosphate. Uridine diphosphate glucuronic acid ammonium serves as a substrate for Arabidopsis UDP-GlcA 4-epimerase 1, and undergoes reversible 4-epimerization to generate UDP-α-D-galacturonic acid.
    Uridine diphosphate glucuronic acid ammonium
  • HY-127035S
    Tristearin-d105 125941-88-0 99.56%
    Tristearin-d105 is the deuterium labeled Tristearin (HY-127035). Tristearin is a triglyceride derived from three units of stearic acid.
    Tristearin-d105
  • HY-128417R
    alpha-D-glucose (Standard) 492-62-6 99.94%
    alpha-D-glucose (Standard) is the analytical standard of alpha-D-glucose. This product is intended for research and analytical applications. \alpha-D-glucose is a monosaccharide that has a more significant insulin stimulating effect than beta-D-glucose[1][2].
    alpha-D-glucose (Standard)
  • HY-132606C
    Scrambled Nedosiran sodium 98%
    Scrambled Nedosiran sodium is a scrambled sequence of Nedosiran sodium (HY-132606A). Scrambled Nedosiran sodium has a random sequence of the amino acids that are the same as the active fragment Nedosiran sodium. Scrambled Nedosiran sodium is usually used as a negative control.
    Scrambled Nedosiran sodium
  • HY-134178A
    5-F-UTP trisodium
    5-F-UTP (5-Fluorouridine-5'-triphosphate) trisodium is a monomeric raw material that can be used for nucleic acid synthesis.
    5-F-UTP trisodium
  • HY-161993A
    (αR)-BI-9787 3043939-19-8 99.11%
    (αR)-BI-9787 is the epimer of BI-9787 (HY-161993). BI-9787 is a zwitterionic inhibitior for ketohexokinase.
    (αR)-BI-9787
  • HY-17386S1
    Rosiglitazone-d4 1132641-21-4 99.72%
    Rosiglitazone-d4 is deuterated labeled Rosiglitazone (HY-17386). Rosiglitazone (BRL 49653) is an orally active selective PPARγ agonist (EC50: 60 nM, Kd: 40 nM). Rosiglitazone is an TRPC5 activator (EC50: 30 μM) and TRPM3 inhibitor. Rosiglitazone can be used in the research of obesity and diabetes, senescence, ovarian cancer.
    Rosiglitazone-d4
  • HY-178589A
    Biotin-7-GMP lithium soluton (100 mM) 98%
    5'-Biotin-G-monophosphate (lithium soluton) (100 mM) (5'-Biotin-G-monophosphate lithium soluton (100 mM)) is a monomeric raw material that can be used for nucleic acid synthesis.
    Biotin-7-GMP lithium soluton (100 mM)
  • HY-41417S1
    Octanoic acid-d3 156779-05-4 99.1%
    Octanoic acid-d3 is the deuterium labeled Octanoic acid. Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes.
    Octanoic acid-d3
  • HY-B0389S7
    D-Glucose-d1-3 106032-60-4 99.90%
    D-Glucose-d-33 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response.
    D-Glucose-d1-3
  • HY-E70239A
    (S)-2-Methylbutyryl-CoA tetrasodium
    (S)-2-Methylbutyryl-CoA tetrasodium is a S-enantiomer of 2-Methylbutyryl-CoA (HY-E70239). 2-Methylbutyryl-CoA is an intermediate of isoleucine metabolism.
    (S)-2-Methylbutyryl-CoA tetrasodium
  • HY-N0537S3
    Xylose-2-13C 131771-69-2 99.89%
    Xylose-2-13C (D-(+)-Xylose-2-13C) is the 13C labeled Xylose (HY-N0537). Xylose (D-(+)-Xylose) is a natural pentose sugar that is catalyzed by xylose isomerase to form xylulose, which is a key step in the anaerobic ethanol fermentation of Xylose. Xylose can be used by microorganisms to produce fuels, chemicals, and bulk industrial enzymes. Xylose provides the substances and energy for cells, as a carbon source for the biosynthesis of high-value chemicals and biofuel. Xylose can be used to fully explore lignocellulose resources and provide a new direction for microbia fermentation.
    Xylose-2-13C
  • HY-N0729S3
    Linoleic acid-13C1 98353-71-0 99.1%
    Linoleic acid-13C1 is the 13C labeled Linoleic acid. Linoleic acid is a common polyunsaturated (PUFA) found in plant-based oils, nuts and seeds. Linoleic acid is a part of membrane phospholipids, and functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism .
    Linoleic acid-13C1
  • HY-N0729S5
    Linoleic acid-d2 31447-29-7 98.52%
    Linoleic Acid-d2 is the deuterium labeled Linoleic acid. Linoleic acid is a common polyunsaturated (PUFA) found in plant-based oils, nuts and seeds. Linoleic acid is a part of membrane phospholipids, and functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism.
    Linoleic acid-d2
  • HY-N2362S2
    DL-Alanine-d3 53795-94-1 98.0%
    DL-Alanine-d3 is the deuterium labeled DL-Alanine. DL-alanine, an amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine, and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver.
    DL-Alanine-d3
  • HY-P991099
    Anti-GLP1R Antibody
    Anti-GLP1R Antibody is a human antibody expressed in CHO cells, targeting GLP1R. Anti-GLP1R Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-GLP1R Antibody
  • HY-P992113
    Evabosmig 3061142-96-6 98%
    Evabosmig is a multispecific antibody targeting SOST, DKK-1 and ALB. Evabosmig can be used for the study of osteoporosis.
    Evabosmig
  • HY-W001472
    Dimethyl pimelate 1732-08-7 ≥98.0%
    Dimethyl pimelate (Pimelic acid dimethyl ester) is an ester product.
    Dimethyl pimelate
  • HY-W013063
    1,2-Dilinoleoyl-sn-glycero-3-phosphocholine 998-06-1 99.16%
    1,2-Dilinoleoyl-sn-glycero-3-phosphocholine is a phospholipid. 1,2-Dilinoleoyl-sn-glycero-3-phosphocholine can be used for obesity research.
    1,2-Dilinoleoyl-sn-glycero-3-phosphocholine
  • HY-W016033
    Pantoprazole sulfide 102625-64-9 98.83%
    Pantoprazole sulfide is a metabolite of Pantoprazole (HY-17507), which is a proton-pump inhibitor.
    Pantoprazole sulfide
Cat. No. Product Name / Synonyms Application Reactivity